pharmaterra.ru
Новая двойная комбинация лечения хронического лимфоцитарного лейкоза (ХЛЛ) оказалась более эффективной, чем общепринятые стандарты химиотерапии. Исследователи обнаружили, что комбинация из двух препаратов более эффективна и менее токсична, чем предыдущий стандарт лечения пациентов с ХЛЛ.
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)
Новая двойная комбинация лечения хронического лимфоцитарного лейкоза (ХЛЛ) оказалась более эффективной, чем общепринятые стандарты химиотерапии. Исследователи обнаружили, что комбинация из двух препаратов более эффективна и менее токсична, чем предыдущий стандарт лечения пациентов с ХЛЛ.
Как было опубликовано в New England Journal of Medicine (31, 07.2019), эксперты обнаружили,
что лечение комбинацией, включающей в себя два препарата таргетной терапии: ритуксимаб (Rituxan) и ибрутиниб (Imbruvica), которые
специфически воздействуют на В-клетки, было более эффективным и лучше
переносимым, чем современные стандарты химиотерапии (флударабин, циклофосфамид и ритуксимаб).
Через три года после лечения у 89,4% пациентов, получавших
комбинацию ритуксимаба (Rituxan) и ибрутиниба (Imbruvica),
не наблюдалось прогрессирования ХЛЛ по сравнению с 72,9% из тех, кто получал
химиотерапию.
Кроме того, 98,8% пациентов, получавших комбинацию
из этих двух препаратов, были живы через 3 года, по сравнению с 91,5% из тех,
кто получал традиционное лечение.
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